Rolev KD, Shu XS, Ying Y (2021) Targeted pharmacotherapy against neurodegeneration and neuroinflammation in early diabetic retinopathy. Strictly controlling serum lipids, especially apoB levels, might be an effective strategy for DR treatment.Īntonetti DA, Silva PS, Stitt AW (2021) Current understanding of the molecular and cellular pathology of diabetic retinopathy. GCL and RNFL thinning was significantly correlated with decreased retinal blood flow in diabetic patients with dyslipidemia. ![]() Moreover, the average GCL thickness was significantly associated with serum apoB levels (all p < 0.05). Serum apoB levels were positively related to low-density lipoprotein (LDL) and total cholesterol (TC). The total area of the VD and PD in the dyslipidemia group was also decreased compared to that of the diabetes group ( p < 0.05) and was found to correlate with GCL and RNFL (all p < 0.01) thicknesses in all diabetic patients. GCL and RNFL thicknesses in patients in the dyslipidemia group were significantly thinner than those in the diabetes group (all p < 0.025). ResultsĪ total of 148 eyes in the diabetes group ( n = 74) and dyslipidemia group ( n = 74) were enrolled. The association of serum apoB and diabetic retinal neurovascular structures was identified with regression analysis. Correlations between inner retinal layer thickness and OCTA metrics were analyzed. Changes in retinal neural structures, including the ganglion cell layer (GCL) and peripapillary retinal nerve fiber layer (RNFL) thicknesses, and microvascular metrics, including macular vessel density (VD) and perfusion density (PD) of the superficial capillary plexus, were measured with optical coherence tomography angiography (OCTA). MethodsĮyes with no clinically visible diabetic retinopathy (DR) from diabetic patients with or without dyslipidemia were included. This can be used as a diagnostic and prognostic factor in cases of DR.To investigate the association of serum apoB concentrations with retinal neurovascular structural alterations in type 2 diabetes patients without clinically visible retinopathy. However, at the nasal quadrant, there were a significant increased thickness of RNFL compared to healthy subject (p value=0.009).Ĭonclusion : Optical coherence tomography can be used to detect neurodegeneration progression in diabetic retinopathy patients by quantitatively measuring the peripapillary RNFL thickness. Result : There were no significant difference of the average RNFL thickness in diabetic retinopathy group compared to healthy subjects. Patients underwent optic nerve OCT imaging, RNFL thickness was recorded globally (average thickness) and segmented for superior, inferior, nasal, and temporal quadrants Methods : A cross-sectional study of 16 eyes from 11 diabetic retinopathy patients and 10 eyes from 7 aged matched healthy subjects for control. This study is to evaluate the changes of peripapillary retinal nerve fiber layer (RNFL) thickness in diabetic retinopathy patients using OCT and compare it to age matched healthy controls. Optical coherence tomography (OCT) can detect retinal neural tissue loss caused by diabetes by measuring the retinal nerve fiber layer (RNFL) thickness on the cross-sectional imaging of the retina. Retinal function loss in diabetic patients is not only caused by microvascular abnormality but also retinal neurodegeneration. ![]() Introduction : Diabetic retinopathy (DR) is a microvascular complication of diabetes and one of the leading causes of blindness.
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